| Primary Identifier | IPR023748 | Type | Family |
| Short Name | Rep_factor-C_ssu_arc |
| description | Replication factor C (RFC) is a multimeric AAA+ protein complex that loads the DNA polymerase processivity clamp PCNA (Proliferating Cell Nuclear Antigen) onto DNA using ATP to drive the reaction []. PCNA functions at multiple levels in directing DNA metabolic pathways []. When bound to DNA, PCNA organises various proteins involved in DNA replication, DNA repair, DNA modification, and chromatin modelling.In contrast to eukaryotic RFC, which has been shown to contain five distinct polypeptides, archaeal RFC contains only two types of subunit - large and small. The exact subunit stoichiometry in archaea is unclear. In Methanobacterium thermoautotrophicum, RFC is reported to be a heterohexamer, composed of four small and two large subunits []. In Sulfolobus solfataricus, meanwhile, it is reported to be a heteropentamer of four small subunits and one large [].This entry represents the archaeal RFC small subunit. |
