| Primary Identifier | IPR008145 | Type | Domain |
| Short Name | GK/Ca_channel_bsu |
| description | This entry represents a domain found in guanylate kinase () and in L-type calcium channel.Guanylate kinase () (GK) []catalyzes the ATP-dependent phosphorylation of GMP into GDP. It is essential for recycling GMP and indirectly, cGMP. In prokaryotes (such as Escherichia coli), lower eukaryotes(such as yeast) and in vertebrates, GK is a highly conserved monomeric protein of about 200 amino acids. GK has been shown [, , ]to be structurally similar to protein A57R (or SalG2R) from various strains of Vaccinia virus.L-type calcium channnels are formed from different alpha-1 subunit isoforms that determine the pharmacological properties of the channel, since they form the drug binding domain. Other properties, such as gating voltage-dependence, G protein modulation and kinase susceptibility, are influenced by alpha-2, delta and beta subunits. |
