Primary Identifier | IPR033105 | Type | Family |
Short Name | CSTF2 |
description | Cleavage stimulation factor subunit 2 (CSTF2, also known as CstF-64) is a member of cleavage stimulation factor complex (CSTF), which is necessary for efficient and accurate polyadenylation of most mRNAs. It is necessary for correct histone mRNA 3' end processing as well as maintenance of pluripotency in mouse embryonic stem cells []. In response to epidermal growth factor (EGF), it serves as a major regulator of 3'UTR shortening []. |