| Primary Identifier | IPR021118 | Type | Family |
| Short Name | Calcitonin |
| description | The calcitonin (CT) gene is alternatively expressed in a tissue-specific manner, producing either the calcium regulatory hormone CT in the thyroid, or the neuropeptide calcitonin gene related peptide (CGRP) in the brain []. In medullary carcinoma of the thyroid, both peptides are produced []. The calcitonin regulatory hormone is a peptide of 32 residues that causes a rapid but short-lived drop in calcium and phosphate levels in the blood by promoting the incorporation of these ions in the bones []. The structure of Oncorhynchus keta (Chum salmon) calcitonin has been studied by 2D NMR in SDS micelles []. The main conformational feature of the hormone is an α-helix from residues 6-22, which includes an amphipathic segment. Two cysteine residues (at positions 1 and 7) form an N-terminal loop, and a C-terminal decapeptide forms a loop that folds back towards the helix []. |
