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Protein Domain : Serine/threonine-protein kinase/endoribonuclease IRE2

Primary Identifier  IPR033523 Type  Family
Short Name  IRE2
description  Human IRE2 induces translational repression through 28S ribosomal RNA cleavage in response to ER stress []. However, mouse IRE2 does not have this function, instead, it plays a role in expression of the DDIT3 transcription factor, required for the unfolded-protein response, growth arrest and apoptosis [].

0 Child Features

1 Parent Features

3 Protein Domain Regions