| Primary Identifier | IPR033197 | Type | Family |
| Short Name | DDAH1 |
| description | DDAH hydrolyzes both N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA), two nitric oxide synthase (NOS) inhibitors to yield L-citrulline and the corresponding alkylamine []. This way DDAH relieves the inhibition of NOS and promotes NO biosynthesis.There are two isoforms of DDHA, DDAH1 and DDAH2. DDAH1 predominates in tissues that express neuronal NOS [], but it is also important in vascular endothelial cells where it plays an important role in degrading the NOS inhibitors and regulating vascular tone [, ]. |
