| Primary Identifier | IPR033324 | Type | Family |
| Short Name | Jmy |
| description | Junction-mediating and regulatory protein (JMY) is a vertebrate protein that was first identified as a transcriptional co-activator of p53 []. It is a regulator of both transcription and actin filament assembly [, , ]. In the nucleus it acts as a transcriptional coactivator and promotes programmed cell death in response to DNA damage [], whereas in the cytoplasm it promotes actin filament assembly []. JMY can either initiate actin filament formation by binding and activating the Arp2/3 complex or nucleate filaments directly in a SPIRE-like fashion [, ]. In both cases, the JMY's actin-regulatory activity relies on a cluster of three actin-binding WH2 domains at its C terminus []. |
