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Protein Domain : Protein BRICK1

Primary Identifier  IPR033378 Type  Family
Short Name  BRICK1
description  Protein BRICK1 (Brk1) is part of the WAVE/SCAR complex, which links upstream Rho-GTPase signalling to the activation of the Arp2/3-complex and mediates actin nucleation [, ]. Brk1 is the only subunit for which a major pool is not associated with the WAVE/SCAR complex []. This free pool of Brk1 is composed of an homotrimer and is a critical precursor for the assembly of the WAVE/SCAR complex [, ]. Brk1 is required for embryonic development and cell transformation [].
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Trail: ProteinDomain




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