| Primary Identifier | IPR045354 | Type | Domain |
| Short Name | BURAN |
| description | This presumed domain can be found in CCRA1/CCRA2 from animals and RSA1 from plants. Cell division cycle and apoptosis regulator protein 1 (CCRA1, also known as CARP-1) is a transcriptional coactivator for nuclear receptors which may contribute to cell growth and apoptosis [, ]. It can act as a both a coactivator and corepressor of the transcription dependent on the androgen receptor (AR), thereby playing an important role in the growth and tumorigenesis of prostate cancer cells []. Cell cycle and apoptosis regulator protein 2 (CCRA2, also known as DBC-1) is a core component of the DBIRD complex, which regulates alternative splicing []. It is also involved in p53-mediated apoptosis [], genomic stability and cellular integrity following UV-induced genotoxic stress [], tumour suppression []and BRCA1 activity []. In Arabidopsis thaliana, SHORT ROOT IN SALT MEDIUM 1 (RSA1, also known as EMB1579) is required for salt tolerance and sodium (Na) homeostasis after salt stress []. RSA1 is localised to the nucleus and the loss of function of RSA1 affects global transcription and mRNA splicing []. |
