| Primary Identifier | IPR033610 | Type | Family |
| Short Name | IRAK3 |
| description | Interleukin-1 receptor-associated kinase 3 (IRAK3/IRAK-M) is a negative regulator of MyD88-dependent Toll-like receptor (TLR) signalling []. It is expressed in monocytes/macrophages and lung epithelial cells. Structurally, IRAK3 consists of a kinase domain (KD) flanked by an N-terminal death domain (DD) involved in binding to other IRAK family members and an unstructured C-terminal domain. The kinase domain lacks the critical active site aspartate residue and IRAK-M appears devoid of kinase activity [, ]. IRAK-M may inhibit inflammation through several mechanisms, including stabilization of MKP-1 []and down-regulation of the non-canonical NFkB pathway []. It can also induce NFkB activation to produce inhibitory molecules as a negative feedback for the pathway []. |
