| Primary Identifier | IPR043044 | Type | Homologous_superfamily |
| Short Name | TPA1/Ofd1_C |
| description | This superfamily entry represents the C-terminal domain of Ofd1 (oxoglutarate and iron-dependent oxygenase, from Schizosaccharomyces pombe), a prolyl 4-hydroxylase-like 2-oxoglutarate-Fe(II) dioxygenase that accelerates the degradation of Sre1N (the N-terminal transcription factor domain of Sre1) in the presence of oxygen []. The domain is conserved from yeasts to humans and was also characterised in S. cerevisiae Tpa1 [, ]. Yeast Sre1 is the orthologue of mammalian sterol regulatory element binding protein (SREBP), and it responds to changes in oxygen-dependent sterol synthesis as an indirect measure of oxygen availability. However, unlike the prolyl 4-hydroxylases that regulate mammalian hypoxia-inducible factor, Ofd1 uses multiple domains to regulate Sre1N degradation by oxygen; the Ofd1 N-terminal dioxygenase domain is required for oxygen sensing and this Ofd1 C-terminal domain accelerates Sre1N degradation in yeasts []. |
