| Primary Identifier | IPR043016 | Type | Homologous_superfamily |
| Short Name | IFT81_N_sf |
| description | This superfamily represents the N-terminal domain found in IFT81 (Intraflagellar transport protein 81) proteins. Crystal structure analysis revealed that IFT81-N adopts the fold of a calponin homology (CH) domain with structural similarity to the kinetochore complex component NDC80 with microtubule (MT)-binding properties. Functional analysis show that IFT74 and IFT81 form a tubulin-binding module required for ciliogenesis. It is suggested that IFT81-N binds the globular domain of tubulin to provide specificity, and IFT74-N recognizes the beta-tubulin tail to increase affinity []. |
