Primary Identifier | IPR043094 | Type | Homologous_superfamily |
Short Name | Nab2/ZC3H14_N_sf |
description | This superfamily represents the N-terminal domain of the nuclear abundant poly(A) RNA-bind protein 2 (Nab2), a yeast heterogeneous nuclear ribonucleoprotein that modulates poly(A) tail length and mRNA. This domain can also be found in Its animal homologue, ZC3H14, which has been shown to control poly(A) tail length in neuronal cells []. The N-terminal domain mediates interactions with the C-terminal globular domain, Myosin-like protein 1 and the mRNA export factor, Gfd1. An essential hydrophobic Phe73 patch on the N-terminal domain is thought to be an important component of the interface between Nab2 and Mlp1 []. |