| Primary Identifier | IPR008717 | Type | Family |
| Short Name | Noggin |
| description | Noggin was first discovered by its ability to induce secondary axis formation in Xenopus embryos []. It is a secreted homodimeric glycoprotein that serves as a BMP (bone morphogenetic protein) antagonist [, ]. It has been found that noggin arrests the differentiation of stromal cells, preventing cellular maturation []. In humans increased noggin activity results in skeletal dysplasia such as proximal symphalangism (SYM1) and multiple synostosis syndrome 1 (SYNS1) []. Noggin maintains prolonged growth of human embryonic stem cells in vitro and regulates the stem cell niche during neurogenesis [, ]. |
