| Primary Identifier | IPR050754 | Type | Family |
| Short Name | FKBP4/5/8-like |
| description | This family of proteins includes immunophilins with peptidyl-prolyl cis-trans isomerase (PPIase) and co-chaperone activities such as Peptidyl-prolyl cis-trans isomerase FKBP4/5 [, ]. FKBP4/5 are also involved in the intracellular trafficking of steroid hormone receptors and play a role in maintaining these receptors in the cytoplasm when unliganded []. FKBP4/5 regulate Akt/AKT1 activity by promoting interaction with PHLPP1, enhancing Akt/AKT1 dephosphorylation and activation [, ]. They also interact with components of the NF-kappaB signaling pathway, influencing kinase activity and IFN production [, ]. FKBP4 plays a role in microtubule dynamics, neuronal growth cone regulation, and may protect against oxidative stress in mitochondria []. Others are involved in protein folding, cell division, adhesion, elongation, and hormonal control of plant development, such as Peptidyl-prolyl cis-trans isomerase PASTICCINO1 from Arabidopsis [, ]. The family is characterised by the presence of TPR repeats and FKBP-type domains. |
