| Primary Identifier | IPR045573 | Type | Domain |
| Short Name | Fut8_N_cat |
| description | This domain includes the N-terminal coil-coiled domain and the catalytic domain of alpha-(1,6)-fucosyltransferase Fut8. The catalytic domain comprises two structures, an open sheet α/β structure, which contains five helices and three β-strands at the N-terminal, and a Rossmann fold that contains five helices and five β-strands at the C-terminal. The latter is conserved among the alpha1,2-, alpha1,6-, and protein O-fucosyltransferases and is similar to GT-B group glycosyltransferases [].Alpha-(1,6)-fucosyltransferase Fut8 catalyses the alpha1,6-linkage of a fucose residue from a donor substrate to N-linked oligosaccharides on glycoproteins in a process called core fucosylation, which is crucial for growth factor receptor-mediated biological functions. Fut8-deficient mice show severe growth retardation, early death, and a pulmonary emphysema-like phenotype []. Fut8 is also implicated to play roles in ageing []and cancer metastasis []. It contains an N-terminal coiled-coil domain, a catalytic domain, and a C-terminal SH3 domain. The SH3 domain of Fut8 is located in the lumen and its role in glycosyl transfer is unclear []. |
