| Primary Identifier | IPR008648 | Type | Family |
| Short Name | ICP27-like |
| description | This entry includes a group of proteins from Herpesviridae, including ICP27 from Human herpesvirus 1. ICP27 is a multifunctional regulatory protein that plays an essential role in viral transcription, nuclear export of intronless RNAs, translation of viral transcripts, and virion host shutoff function []. It interacts with the nuclearpore complex through Nup62 and may compete with some host cell transport receptors for binding, resulting in inhibition of those host transport pathways []. It also regulates alternative pre-mRNA polyadenylation and splicing in a sequence-dependent manner []. |
