| Primary Identifier | IPR021887 | Type | Domain |
| Short Name | DAB2P_C |
| description | This entry represents a domain found at the C terminus of some GTPase-activating proteins (also known as GAP) found in animals, including Disabled homologue 2-interacting protein (DAB2P) and Ras/Rap GTPase-activating protein SynGAP (SYGP1). DAB2P functions as a tumour suppressor that is also involved in several processes such as innate immune response and inflammation and plays a key role in brain development and function [, , ]. SYGP1 is essential for postsynaptic signalling and has been related to brain injury, leading to long-term learning and memory deficits [, ].This domain, which is found associated with the RasGAP domain () and the C2 domain (), includes a coiled-coil domain that forms a parallel trimer in solution []. |
