| Primary Identifier | IPR006331 | Type | Family |
| Short Name | ADGF |
| description | Members of this family have been described as secreted proteins with growth factor activity and regions of adenosine deaminase homology in insects, molluscs, and vertebrates [].Adenosine deaminase-related growth factors (ADGF) are also known as CECR1 in vertebrates. They are a novel family of growth factors with sequence similarity to classical cellular adenosine deaminase. In Xenopus, it is essential for growth factor activity and is expressed in the somites, pronephros, eyes, cement gland, neural tube, and neural floor plate of the embryos []. It is also essential for insect development []. The mollusc derived growth factor (MDGF) is a member of the adenosine deaminase-related growth factor (ADGF) subfamily. ADGFs from vertebrates and invertebrates contain both an ADA domain and a novel N-terminal region of about 100 amino acids []. Adenosine deaminase (ADA) is an enzyme that catalyses the irreversible deamination of adenosine and deoxyadenosine to inosine and deoxyinosine []. Catalytic residues involved in ADA activity are conserved in ADGFs, and inhibitors of ADA can block ADGF activity []. |
