| Primary Identifier | IPR045913 | Type | Family |
| Short Name | TBC20/Gyp8-like |
| description | This entry represents a group of Rab GTPase-activating proteins (RabGAPs), including TBC20 from humans and Gyp8 from Saccharomyces cerevisiae. They contain the TBC/rab GTPase-activating protein (GAP) domain.TBC20 can accelerate the intrinsic GTP hydrolysis rate by more than five orders of magnitude for Rab1 and Rab2 small GTPase families [, , ]. This protein have been related to numerous diseases due to its critical role in cellular processes [, , ]. It was also seen to be essential for the replication and assembly of hepatitis C virus (HCV) [].Gyp8 is involved in the regulation of ER to Golgi vesicle transport in yeast mainly by activating the Ypt/Rab-GTPase Ypt1 []. |
