| Primary Identifier | IPR033763 | Type | Domain |
| Short Name | SCML2_RBR |
| description | SCML2 is a mammalian Polycomb-group protein, which associates with the Polycomb repressive complex-1 (PRC1) that is essential for the epigenetic regulation of gene expression. Isoform SCML2A has been shown to bind to PRC1 via its SPM domain and to interact with ncRNAs through a novel RNA-binding region (RBR). The RBR is necessary for targeting of SCML2A to chromatin and PRC1 recruitment, suggesting a role for ncRNAs in regulating SCML2 function [].This entry represents the RNA-binding region of SCML2, also found in other Polycomb-group proteins. |
