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Protein Domain : Negative modulator of initiation of replication SeqA, N-terminal

Primary Identifier  IPR033761 Type  Domain
Short Name  SeqA_N
description  The binding of SeqA protein to hemimethylated GATC sequences is important in the negative modulation of chromosomal initiation at oriC, and in the formation of SeqA foci necessary for Escherichia coli chromosome segregation []. SeqA tetramers are able to aggregate or multimerise in a reversible, concentration-dependent manner []. Apart from its function in the control of DNA replication, SeqA may also be a specific transcription factor [].This family represents the N-terminal domain of SeqA: a short domain that is reported to mediate the dimerisation of SeqA [].

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