| Primary Identifier | IPR045786 | Type | Domain |
| Short Name | RhoGAP_pG1_pG2 |
| description | The RhoGAPs (GTPase-activating proteins) regulates Rho GTP hydrolysis and are important for proper Rho signalling. This entry represents a domain found in p190RhoGAP-A (ARHGAP35) and p190RhoGAP-B (ARHGAP5). 190RhoGAP-A/B contain a GTP-binding GTPase domain, four FF domains, two GTPase-like folds (pG1 and pG2) in the middle domain and a C-terminal GAP domain. This entry represents pG1 and pG2 which are important for GAP activity toward RhoA. 190RhoGAP-A/B were classified as pseudoGTPases as they lack nucleotide-binding activity. Crystal structures revealed a small GTPase fold in both cases with a central 6-stranded β-sheet surrounded by four α-helices []. |
