| Primary Identifier | IPR043178 | Type | Homologous_superfamily |
| Short Name | PLpro_thumb_sf_CoV |
| description | All coronaviruses such as the SARS virus and the Middle East Respiratory Syndrome (MERS) virus encode in their genomes at least one papain-like protease (PLpro) enzyme which cleaves the viral replicase polyproteins at three sites releasing non-structural protein NSP1, NSP2 and NSP3. PLpro also possesses deubiquitinating and deISGylating activities. These have been suggested to suppress the host antiviral response by counteracting the post-translational modification of signalling molecules that activate the innate immune response. PLpro is made up of an N-terminal ubiquitin-like domain (found in many ubiquitin-specific proteases or USPs) and a C-terminal catalytic domain containing a right-handed fingers, palm, and thumb domain organisation [, , , ].This entry represents the thumb domain of the papain-like viral protease from coronavirus. It consists of 6 α-helices in MERS-CoV []and 4 α-helices in SARS-CoV []. |
