| Primary Identifier | IPR008828 | Type | Family |
| Short Name | Sin1/Avo1 |
| description | This entry includes MAPKAP1/Sin1 from animals, Sin1 from fission yeast, Avo1 from budding yeast and Rip3 from Slime mold. They are part of the Target Of Rapamycin Complex 2 (TORC2) complex, which plays an essential role in signal transduction []. The mammalian TORC2 consists of mTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR [, , , , ]. Within TORC2, MAPKAP1 is required for complex formation and TORC2 kinase activity []. The budding yeast TORC2 is composed of Avo1, Avo2, Tsc11, Lst8, Bit61, Slm, Slm2 and Tor2 [, ]. |
