| Primary Identifier | IPR045817 | Type | Domain |
| Short Name | OPA1_C |
| description | This entry represents the C-terminal domain of Dynamin-like GTPase OPA1. This protein is involved in mitochondrial fusion and inner membrane remodelling, essential for normal mitochondrial morphology by regulating the equilibrium between mitochondrial fusion and mitochondrial fission [, , ]. Mutations in human OPA1 cause optic atrophy []. This domain includes the helix bundle (HB) domains HB1 (at the extreme C-terminal) and HB2 (equivalent to bundle signaling element (BSE) and to the stalk domain of dynamin-1, respectively) that associate with the N-terminal G domain and the lipid-interacting stalk (LIS, equivalent to the PH domain of dynamin-1) []. |
