| Primary Identifier | IPR051134 | Type | Family |
| Short Name | PPP_phosphatase |
| description | The PPP phosphatase family is involved in a variety of cellular processes including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels, circadian rhythms, and phototransduction. Members of the family dephosphorylate a wide range of proteins such as kinases, nuclear receptors, SMAD proteins, and TAU/MAPT, influencing signaling pathways related to steroid and thyroid hormones, calcium, fatty acids, TGF-beta, oxidative and genotoxic stresses. They participate in DNA damage response mechanisms, checkpoint activation, and DNA damage repair. Some members regulate adipogenesis and circadian rhythms, while others are implicated in the regulation of the Hsp90 chaperone machinery and photoreceptor function. The family includes subfamilies such as PP-5 (PP-T) and PP-7, with some members possessing TPR repeats for protein-protein interactions and autoinhibition, or EF-hands for calcium activation. |
