| Primary Identifier | IPR051727 | Type | Family |
| Short Name | DnaJ_C3_Co-chaperones |
| description | The DnaJ homolog subfamily C member 3 protein family is involved in various stress response mechanisms, particularly the unfolded protein response (UPR) during endoplasmic reticulum (ER) stress. Family members act as co-chaperones, interacting with molecular chaperones such as HSPA8/HSC70 to stimulate ATPase activity and assist in protein folding. They play roles in inhibiting the phosphorylation of eIF-2-alpha, thus regulating protein synthesis under stress conditions. Some members are implicated in cold adaptation, virulence factor production, and ER homeostasis. They may also participate in nuclear membrane fusion during mating and contribute to cell wall architecture maintenance. The family is characterized by the presence of TPR repeats, which mediate interaction with unfolded polypeptides, and a J domain essential for chaperone activity enhancement. |
