| Primary Identifier | IPR022241 | Type | Domain |
| Short Name | iRhom1_2_N |
| description | This entry represents an N-terminal helical segment of inactive rhomboid proteins (iRhom1/2), which are catalytically inactive rhomboid protease homologues that play crucial roles within the secretory pathway, including protein degradation, trafficking regulation, and inflammatory signalling []. These are metazoan specific pseudoproteases which regulate ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, acting as trafficking factors that escort ADAM17 from the ER to the later secretory pathway. They are required for the cleavage and release of a variety of membrane-associated proteins []. iRhoms share a common structure comprising 7-helix transmembrane-spanning domains (TMDs) which is a conserved rhomboid fold (), an extended N-terminal cytosolic domain and a luminal loop [, ].These proteins have been linked to the development and progression of several autoimmune diseases including rheumatoid arthritis, lupus nephritis, as well as hemophilic arthropathy []and also in neurological disorders such as Alzheimer's and Parkinson's diseases, inflammation, cancer and skin diseases []. |
