| Primary Identifier | IPR056159 | Type | Domain |
| Short Name | Beta-prop_IFT121_TULP_N |
| description | This entry represents a ��-propeller domain found at the N-terminal of IFT121 (which corresponds to the first one) and TULP4 proteins. TULP4 may be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex. IFT-A polymerises and interacts with IFT-B, and uses an array of ��-propeller and TPR domains to create 'carriages' of the IFT train that engage TULP adaptor proteins []. Proteins in this entry are part of the non-core subcomplex, together with IFT43 and IFT139 [, ].IFT121 (also known as WDR35) is a component of the IFT complex A (IFT-A), which is required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors that is involved in ciliogenesis and ciliary protein trafficking [, , ]. This protein plays a role in cilia assembly and maintenance [, , ]. IFT121 contains a zinc finger with rubredoxin-like fold []. Knock-out IFT121 cells showed defective retrograde trafficking within cilia []. |
