| Primary Identifier | IPR056153 | Type | Domain |
| Short Name | IFT122/SMU1_beta-prop |
| description | This entry represents a ��-propeller found at the N-terminal end of IFT122 and at the C-terminal of SMU1. Members of this group are found in eukaryotes and bacteria.Intraflagellar transport protein 122 homolog (IFT122) is one of the core components (together with WDR19/IFT144 and IFT140) of the IFT-A complex which is required for retrograde ciliary transport and entry into cilia of G protein-coupled receptors (GPCRs), being involved in cilia function and/or assembly [, ]. IFT-A polymerises interacts with IFT-B, and uses an array of ��-propeller and TPR domains to create 'carriages' of the IFT train that engage TULP adaptor proteins [].Human WD40 repeat-containing protein SMU1 is involved in pre-mRNA splicing as a component of the spliceosome [], and is required for normal accumulation of IK []. |
