| Primary Identifier | IPR056273 | Type | Domain |
| Short Name | CDK5RAP2_MYOME_CC |
| description | This domain is found in human CDK5 regulatory subunit-associated protein 2 (CDK5RAP2), myomegalin (MYOME, also known as PDE4DIP) and related sequences mainly from vertebrates.CDK5RAP2 is a potential regulator of CDK5 activity that plays a role in the spindle checkpoint activation and regulates centrosomal maturation []. It plays a role in the spindle checkpoint activation by acting as a transcriptional regulator of both BUBR1 and MAD2 promoter. Together with EB1/MAPRE1, it may promote microtubule polymerization, bundle formation, growth and dynamics at the plus []. It forms a complex with MYOME isoform 13/MMG8/SMYLE, MAPRE1 and AKAP9, to contribute to microtubules nucleation and extension from the centrosome to the cell periphery []. MYOME participates in microtubule dynamics, promoting microtubule assembly. Depending upon the cell context, may act at the level of the Golgi apparatus or that of the centrosome [, , , ]. It forms a complex with AKAP9, and recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarised cell movement [, ].This entry represents a centrally located region that forms an ��-helical coiled-coil (CC) in these proteins. |
