| Primary Identifier | IPR056424 | Type | Domain |
| Short Name | Beta-prop_GEMI5_2nd |
| description | This entry represents the second ��-propeller found in Gem-associated protein 5 (GEMI5) from vertebrates and its orthologue from Drosophila melanogaster, Protein rigor mortis (RIG). The ��-propellers in GEMI5 bind small nuclear RNAs (snRNAs) playing a critical role in the assembly of the heptameric Sm protein core on snRNAs and the biogenesis of small nuclear ribonucleoproteins (snRNPs) [, ]. Apart of being a component of the survival motor neuron (SMN) complex, it is a nuclear receptor-interacting protein required for the response to steroid hormone ecdysone during larval development in which this domain acts as a specific protein-protein interaction domain [].GEMI5 is a component of the survival of motor neurons (SMN) complex, that binds small nuclear RNAs (snRNAs). The SMN complex assembles the heptameric Sm protein core on snRNAs playing a critical role in the biogenesis of small nuclear ribonucleoproteins (snRNPs) [, ]. GEMI5 is also implicated in translation control, and gene expression reprogramming []. GEMI5 from animals share a domain architecture consisting of two N-terminal ��-propellers followed by a TPR domain and a C-terminal RNA-binding domain. |
