| Primary Identifier | IPR056432 | Type | Domain |
| Short Name | Beta-prop_GEMI5_1st |
| description | This entry represents the first ��-propeller found at the N-terminal of Protein rigor mortis (RIG) from Drosophila melanogaster, also known as Gem-associated protein 5 (GEMI5), the orthologue of GEMI5 from vertebrates []. RIG, apart from being a component of the survival motor neuron (SMN) complex, it is a nuclear receptor-interacting protein required for the response to steroid hormone ecdysone during larval development [].GEMI5 is a component of the survival of motor neurons (SMN) complex, that binds small nuclear RNAs (snRNAs). The SMN complex assembles the heptameric Sm protein core on snRNAs playing a critical role in the biogenesis of small nuclear ribonucleoproteins (snRNPs) [, ]. GEMI5 is also implicated in translation control, and gene expression reprogramming []. GEMI5 from animals share a domain architecture consisting of two N-terminal ��-propellers followed by a TPR domain and a C-terminal RNA-binding domain. |
