| Primary Identifier | IPR056802 | Type | Domain |
| Short Name | ATR-like_M-HEAT |
| description | This region of HEAT repeats is found in human Serine/threonine-protein kinase ATR andsimilar eukaryotic proteins. This entry represents the M-HEAT region.This region is also found in Serine/threonine-protein kinase MEC1 from Saccharomyces cerevisiae, which activates checkpoint signalling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor [, , , ].ATR acts as a DNA damage sensor and is associated with severe disorders such as Seckel syndrome 1. This protein is organised into a large N-terminal ��-solenoid containing HEAT repeats, a FAT (FRAP, ATM, TRRAP) domain (), a kinase domain (), and a C-terminal short segment referred to as FATC (). N-terminal part has two continuous HEAT repeat regions, the N-HEAT and the M-HEAT. The FAT domain contains TPR (tetratricopeptide) repeats followed by a HEAT repeat domain []. |
