| Primary Identifier | IPR052596 | Type | Family |
| Short Name | AMBRA1_autophagy |
| description | The AMBRA1 family proteins are substrate-recognition components of the DCX E3 ubiquitin-protein ligase complex, playing a pivotal role in cell cycle control and autophagy. They mediate polyubiquitination and degradation of various target proteins, including BECN1 and cyclin-D, thereby regulating the G1 to S phase transition and maintaining genomic integrity. The AMBRA1 family also modulates the BECN1-PIK3C3 complex, essential for autophagosome nucleation and protein turnover, particularly during neuronal development. Additionally, these proteins are involved in mitophagy, either by interacting with PRKN and LC3 proteins or by acting as cofactors for ubiquitination enzymes. They contribute to Treg differentiation by promoting FOXO3 dephosphorylation and are implicated in intracellular trafficking and transcription regulation. The family's interaction with dynein light chains and protein phosphatase 2A highlights its role in cytoskeletal tethering and signal transduction. |
