| First Author | Haupt WF | Year | 2004 |
| Journal | J Neurol Sci | Volume | 217 |
| Issue | 1 | Pages | 83-8 |
| PubMed ID | 14675614 | Mgi Jnum | J:87422 |
| Mgi Id | MGI:2687106 | Doi | 10.1016/j.jns.2003.09.004 |
| Citation | Haupt WF, et al. (2004) Nerve conduction velocity measurements reveal the functional deficit in ceramide galactosyl transferase-deficient (cgt-/-) mice. J Neurol Sci 217(1):83-8 |
| abstractText | Biochemical and ultrastructural studies of ceramide galactosyltransferase (CGT) in a CGT-deficient mouse line (cgt-/-) were complemented by nerve conduction velocity (NCV) measurements in motor nerves (sciatic nerve in the hind limbs) of wild type (wt) and cgt-/- mice. Stimulation and recording electrodes were adapted to the small size of developing mice during their myelination period. Motor NCVs in wt mice ranged between 16 and 26 m/s but in cgt-/- mice between 6 and 13 m/s, which corresponds to the conductance of unmyelinated peripheral nerves.These electrophysiologic data provide additional functional parameters to the neuropathology of a new form of a dysmyelinosis. |
