| First Author | Cao Y | Year | 2022 |
| Journal | Curr Biol | Volume | 32 |
| Issue | 22 | Pages | 4783-4796.e3 |
| PubMed ID | 36179691 | Mgi Jnum | J:332184 |
| Mgi Id | MGI:7407843 | Doi | 10.1016/j.cub.2022.09.016 |
| Citation | Cao Y, et al. (2022) Post-developmental plasticity of the primary rod pathway allows restoration of visually guided behaviors. Curr Biol 32(22):4783-4796.e3 |
| abstractText | The formation of neural circuits occurs in a programmed fashion, but proper activity in the circuit is essential for refining the organization necessary for driving complex behavioral tasks. In the retina, sensory deprivation during the critical period of development is well known to perturb the organization of the visual circuit making the animals unable to use vision for behavior. However, the extent of plasticity, molecular factors involved, and malleability of individual channels in the circuit to manipulations outside of the critical period are not well understood. In this study, we selectively disconnected and reconnected rod photoreceptors in mature animals after completion of the retina circuit development. We found that introducing synaptic rod photoreceptor input post-developmentally allowed their integration into the circuit both anatomically and functionally. Remarkably, adult mice with newly integrated rod photoreceptors gained high-sensitivity vision, even when it was absent from birth. These observations reveal plasticity of the retina circuit organization after closure of the critical period and encourage the development of vision restoration strategies for congenital blinding disorders. |
