| First Author | Wu R | Year | 2020 |
| Journal | Front Immunol | Volume | 11 |
| Pages | 1702 | PubMed ID | 32849598 |
| Mgi Jnum | J:324376 | Mgi Id | MGI:6729019 |
| Doi | 10.3389/fimmu.2020.01702 | Citation | Wu R, et al. (2020) Identification and Regulation of TCRalphabeta(+)CD8alphaalpha(+) Intraepithelial Lymphocytes in Murine Oral Mucosa. Front Immunol 11:1702 |
| abstractText | TCRalphabeta(+)CD8alphaalpha(+) intraepithelial lymphocytes (IELs) are abundant in gastrointestinal (GI) tract and play an important role in regulation of mucosal immunity and tolerance in the gut. However, it is unknown whether TCRalphabeta(+)CD8alphaalpha(+) IELs exist in the oral mucosa and if yes, what controls their development. We here identified and characterized TCRalphabeta(+)CD8alphaalpha(+) IELs from the murine oral mucosa. We showed that the number and function of TCRalphabeta(+)CD8alphaalpha(+) IELs were regulated by TGF-beta. We further revealed that oral TCRalphabeta(+)CD8alphaalpha(+) IELs could be altered under systemic inflammatory conditions and by antibiotic treatment at the neonatal age of the mice. Our findings have revealed a previously unrecognized population of oral IELs that may regulate oral mucosal immune responses. |
