| First Author | Melzer S | Year | 2012 |
| Journal | Science | Volume | 335 |
| Issue | 6075 | Pages | 1506-10 |
| PubMed ID | 22442486 | Mgi Jnum | J:252090 |
| Mgi Id | MGI:6107582 | Doi | 10.1126/science.1217139 |
| Citation | Melzer S, et al. (2012) Long-range-projecting GABAergic neurons modulate inhibition in hippocampus and entorhinal cortex. Science 335(6075):1506-10 |
| abstractText | The hippocampus and entorhinal cortex play a pivotal role in spatial learning and memory. The two forebrain regions are highly interconnected via excitatory pathways. Using optogenetic tools, we identified and characterized long-range gamma-aminobutyric acid-releasing (GABAergic) neurons that provide a bidirectional hippocampal-entorhinal inhibitory connectivity and preferentially target GABAergic interneurons. Activation of long-range GABAergic axons enhances sub- and suprathreshold rhythmic theta activity of postsynaptic neurons in the target areas. |
