| First Author | Waskow C | Year | 2002 |
| Journal | Immunity | Volume | 17 |
| Issue | 3 | Pages | 277-88 |
| PubMed ID | 12354381 | Mgi Jnum | J:79128 |
| Mgi Id | MGI:2387257 | Doi | 10.1016/s1074-7613(02)00386-2 |
| Citation | Waskow C, et al. (2002) Viable c-Kit(W/W) Mutants Reveal Pivotal Role for c-Kit in the Maintenance of Lymphopoiesis. Immunity 17(3):277 |
| abstractText | Mice lacking the receptor tyrosine kinase c-Kit (c-Kit(W/W)) have hematopoietic defects causing perinatal death. We have identified a viable c-Kit(W/W) mouse, termed the 'Vickid' mouse. Around birth, c-Kit plays a redundant role in T and no role in B cell development. Here, we show an age-dependent, progressive decline of pro-T and pro-B cells accompanied by loss of common lymphoid progenitors in the bone marrow in adult mice lacking c-Kit. Adult c-Kit(W/W) hematopoietic stem cells can engraft in host bone marrow but fail to radioprotect, form spleen colonies, or establish sustained lymphopoiesis. These defects in adult T and B cell development are also evident in a second viable c-Kit(W/W) strain, rescued by overexpression of erythropoietin. |
