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Allele : Kit<tm1.1Gnf> KIT proto-oncogene receptor tyrosine kinase; targeted mutation 1.1, Genomics Institute of the Novartis Research Foundation
Primary Identifier  MGI:5620943 Allele Type  Targeted
Attribute String  Not Specified Gene  Kit
Transmission  Germline Strain of Origin  B6.Cg-Thy1<a>
Is Recombinase  false Is Wild Type  false
molecularNote  A targeting construct introduced a C to T point mutation in exon 14 that results in the amino acid substitution of isoleucine for threonine at position 670 (T607I). Flp-mediated recombination removed an FRT-flanked neomycin resistance cassette with a 3' loxP site introduced downstream of the modified exon 14.
  • mutations:
  • Single point mutation,
  • Insertion
  • synonyms:
  • Kit<T670I>,
  • Kit<T670I>
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1 Feature

Genome

0 Expresses

0 Mutation Involves

Phenotype

Mouse alleles --> Mammalian phenotypes (MP terms)

 

Other

1 Carried By

0 Driven By

4 Publication categories





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