| First Author | Singaraja RR | Year | 2011 |
| Journal | Hum Mol Genet | Volume | 20 |
| Issue | 20 | Pages | 3899-909 |
| PubMed ID | 21775500 | Mgi Jnum | J:175800 |
| Mgi Id | MGI:5287334 | Doi | 10.1093/hmg/ddr308 |
| Citation | Singaraja RR, et al. (2011) Altered palmitoylation and neuropathological deficits in mice lacking HIP14. Hum Mol Genet 20(20):3899-909 |
| abstractText | Huntingtin interacting protein 14 (HIP14, ZDHHC17) is a huntingtin (HTT) interacting protein with palmitoyl transferase activity. In order to interrogate the function of Hip14, we generated mice with disruption in their Hip14 gene. Hip14-/- mice displayed behavioral, biochemical and neuropathological defects that are reminiscent of Huntington disease (HD). Palmitoylation of other HIP14 substrates, but not Htt, was reduced in the Hip14-/- mice. Hip14 is dysfunctional in the presence of mutant htt in the YAC128 mouse model of HD, suggesting that altered palmitoylation mediated by HIP14 may contribute to HD. |
