| First Author | Reis BS | Year | 2022 |
| Journal | Science | Volume | 377 |
| Issue | 6603 | Pages | 276-284 |
| PubMed ID | 35857588 | Mgi Jnum | J:327132 |
| Mgi Id | MGI:7328655 | Doi | 10.1126/science.abj8695 |
| Citation | Reis BS, et al. (2022) TCR-Vgammadelta usage distinguishes protumor from antitumor intestinal gammadelta T cell subsets. Science 377(6603):276-284 |
| abstractText | gammadelta T cells represent a substantial fraction of intestinal lymphocytes at homeostasis, but they also constitute a major lymphocyte population infiltrating colorectal cancers (CRCs); however, their temporal contribution to CRC development or progression remains unclear. Using human CRC samples and murine CRC models, we found that most gammadelta T cells in premalignant or nontumor colons exhibit cytotoxic markers, whereas tumor-infiltrating gammadelta T cells express a protumorigenic profile. These contrasting T cell profiles were associated with distinct T cell receptor (TCR)-Vgammadelta gene usage in both humans and mice. Longitudinal intersectional genetics and antibody-dependent strategies targeting murine gammadelta T cells enriched in the epithelium at steady state led to heightened tumor development, whereas targeting gammadelta subsets that accumulate during CRC resulted in reduced tumor growth. Our results uncover temporal pro- and antitumor roles for gammadelta T cell subsets. |
