| First Author | Dao T | Year | 2004 |
| Journal | Eur J Immunol | Volume | 34 |
| Issue | 12 | Pages | 3542-52 |
| PubMed ID | 15549774 | Mgi Jnum | J:94598 |
| Mgi Id | MGI:3513577 | Doi | 10.1002/eji.200425546 |
| Citation | Dao T, et al. (2004) Development of CD1d-restricted NKT cells in the mouse thymus. Eur J Immunol 34(12):3542-52 |
| abstractText | Using genetic and phenotypic analyses, we have analyzed the developmental pathway of mouse CD1d-restricted invariant NKT cells. We provide strong evidence that similar to conventional T cells, positive selection of NKT cells occurs during a CD4(+)CD8(+) stage. Later stages of NKT cell development involved the down-regulation of both TCR and CD4 levels and therefore diverge from conventional T cell development pathways. A unique and complete dependency for development on Fyn, a Src family kinase member, also distinguishes the NKT cell and conventional T cell populations. |
