| First Author | Endres M | Year | 2000 |
| Journal | J Cereb Blood Flow Metab | Volume | 20 |
| Issue | 1 | Pages | 139-44 |
| PubMed ID | 10616802 | Mgi Jnum | J:60087 |
| Mgi Id | MGI:1352609 | Doi | 10.1097/00004647-200001000-00018 |
| Citation | Endres M, et al. (2000) Ischemic brain damage in mice after selectively modifying BDNF or NT4 gene expression. J Cereb Blood Flow Metab 20(1):139-44 |
| abstractText | The neurotrophins and the tyrosine kinase (Trk) B receptor may play a protective role in the pathophysiology of cerebral ischemia. In this study, the authors investigated whether reducing endogenous expression of TrkB-binding neurotrophins modifies the susceptibility to ischemic injury after 1-hour middle cerebral artery occlusion followed by 23 hours of reperfusion in a filament middle cerebral artery occlusion model. Mice lacking both alleles for neurotrophin-4 (nt4-/-) or deficient in a single allele for brain-derived neurotrophic factor (bdnf+/-) exhibited larger cerebral infarcts compared to wild-type inbred 129/SVjae mice (68% and 91%, respectively, compared to controls). Moreover, lesions were larger (21%) in nt4-/- mice after permanent middle cerebral artery occlusion. Hence, expression of both NT4 and BDNF, and by inference the TrkB receptor, confers resistance to ischemic injury. |
