| First Author | Ikeno Y | Year | 2009 |
| Journal | J Gerontol A Biol Sci Med Sci | Volume | 64 |
| Issue | 5 | Pages | 522-9 |
| PubMed ID | 19228785 | Mgi Jnum | J:236361 |
| Mgi Id | MGI:5805773 | Doi | 10.1093/gerona/glp017 |
| Citation | Ikeno Y, et al. (2009) Reduced incidence and delayed occurrence of fatal neoplastic diseases in growth hormone receptor/binding protein knockout mice. J Gerontol A Biol Sci Med Sci 64(5):522-9 |
| abstractText | Although studies of Ames and Snell dwarf mice have suggested possible important roles of the growth hormone (GH)/insulin-like growth factor-1 (IGF-1) axis in aging and age-related diseases, the results cannot rule out the possibility of other hormonal changes playing an important role in the life extension exhibited by these dwarf mice. Therefore, growth hormone receptor/binding protein (GHR/BP) knockout (KO) mice would be valuable animals to directly assess the roles of somatotropic axis in aging and age-related diseases because the primary hormonal change is due to GH/IGF-1 deficiency. Our pathological findings showed GHR/BP KO mice to have a lower incidence and delayed occurrence of fatal neoplastic lesions compared with their wild-type littermates. These changes of fatal neoplasms are similar to the effects observed with calorie restriction and therefore could possibly be a major contributing factor to the extended life span observed in the GHR/BP KO mice. |
