| First Author | Zhai X | Year | 2021 |
| Journal | Sci Adv | Volume | 7 |
| Issue | 49 | Pages | eabk0490 |
| PubMed ID | 34860557 | Mgi Jnum | J:329131 |
| Mgi Id | MGI:6836522 | Doi | 10.1126/sciadv.abk0490 |
| Citation | Zhai X, et al. (2021) Mitochondrial C1qbp promotes differentiation of effector CD8(+) T cells via metabolic-epigenetic reprogramming. Sci Adv 7(49):eabk0490 |
| abstractText | Early-activated CD8(+) T cells increase both aerobic glycolysis and mitochondrial oxidative phosphorylation (OXPHOS). However, whether and how the augmentation of OXPHOS regulates differentiation of effector CD8(+) T cell remains unclear. Here, we found that C1qbp was intrinsically required for such differentiation in antiviral and antitumor immune responses. Activated C1qbp-deficient CD8(+) T cells failed to increase mitochondrial respiratory capacities, resulting in diminished acetyl-coenzyme A as well as elevated fumarate and 2-hydroxyglutarate. Consequently, hypoacetylation of H3K27 and hypermethylation of H3K27 and CpG sites were associated with transcriptional down-regulation of effector signature genes. The effector differentiation of C1qbp-sufficient or C1qbp-deficient CD8(+) T cells was reversed by fumarate or a combination of histone deacetylase inhibitor and acetate. Therefore, these findings identify C1qbp as a pivotal positive regulator in the differentiation of effector CD8(+) T cells and highlight a metabolic-epigenetic axis in this process. |
