| First Author | Pai SY | Year | 2003 |
| Journal | Immunity | Volume | 19 |
| Issue | 6 | Pages | 863-75 |
| PubMed ID | 14670303 | Mgi Jnum | J:86996 |
| Mgi Id | MGI:2682543 | Doi | 10.1016/s1074-7613(03)00328-5 |
| Citation | Pai SY, et al. (2003) Critical roles for transcription factor GATA-3 in thymocyte development. Immunity 19(6):863-75 |
| abstractText | The transcription factor GATA-3 is expressed at every stage of thymic development, but its role in thymocyte differentiation is unknown. The fact that RAG chimeric animals lacking GATA-3 cannot generate early thymocytes from common lymphoid progenitors has thus far precluded investigation of the function of GATA-3 in the thymus. To address this, we generated mice deficient in GATA-3 at early and late stages of thymic differentiation. Our studies revealed that GATA-3 is involved in beta selection and is indispensable for single-positive CD4 thymocyte development. Thus, our data demonstrate that the coordinated and regulated expression of GATA-3 at each stage of thymic development is critical for the generation of mature T cells. |
