| First Author | Petersen C | Year | 2019 |
| Journal | Science | Volume | 365 |
| Issue | 6451 | PubMed ID | 31346040 |
| Mgi Jnum | J:277747 | Mgi Id | MGI:6333016 |
| Doi | 10.1126/science.aat9351 | Citation | Petersen C, et al. (2019) T cell-mediated regulation of the microbiota protects against obesity. Science 365(6451) |
| abstractText | The microbiota influences obesity, yet organisms that protect from disease remain unknown. During studies interrogating host-microbiota interactions, we observed the development of age-associated metabolic syndrome (MetS). Expansion of Desulfovibrio and loss of Clostridia were key features associated with obesity in this model and are present in humans with MetS. T cell-dependent events were required to prevent disease, and replacement of Clostridia rescued obesity. Inappropriate immunoglobulin A targeting of Clostridia and increased Desulfovibrio antagonized the colonization of beneficial Clostridia. Transcriptional and metabolic analysis revealed enhanced lipid absorption in the obese host. Colonization of germ-free mice with Clostridia, but not Desulfovibrio, down-regulated genes that control lipid absorption and reduced adiposity. Thus, immune control of the microbiota maintains beneficial microbial populations that constrain lipid metabolism to prevent MetS. |
